Abstract | PURPOSE OF REVIEW: The pathophysiological role of the ( pro)renin receptor is yet to be established. The present review summarizes the findings, suggesting that it may play pathological role in cardiac and renal fibrosis, and in hypertensive and diabetic nephropathy. RECENT FINDINGS: SUMMARY: The experimental data confirmed the pivotal role of the receptor in cell surface generation of angiotensin and suggested its potential role in tissue fibrosis via receptor activation and intracellular signaling. The data also questioned the ability of soon available renin inhibitors to inhibit the activity of receptor-bound renin and prorenin, and the benefit of a new class of drug--( pro)renin receptor blockers--to prevent tissue damage.
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Authors | Geneviève Nguyen |
Journal | Current opinion in nephrology and hypertension
(Curr Opin Nephrol Hypertens)
Vol. 16
Issue 2
Pg. 129-33
(Mar 2007)
ISSN: 1062-4821 [Print] England |
PMID | 17293688
(Publication Type: Journal Article, Review)
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Chemical References |
- Angiotensins
- Receptor, IGF Type 2
- Receptors, Cell Surface
- Renin
- Prorenin Receptor
|
Topics |
- Angiotensins
(metabolism)
- Animals
- Diabetes Mellitus
(metabolism)
- Fibrosis
(metabolism)
- Hypertension
(metabolism)
- Receptor, IGF Type 2
(metabolism)
- Receptors, Cell Surface
(metabolism)
- Renin
(metabolism)
- Renin-Angiotensin System
(physiology)
- Prorenin Receptor
|