[The activity of 11beta-hydroxysteroid dehydrogenase of rat kidney and liver at inherited stress-induced arterial hypertension].

Abstract

11beta-hydroxysteroid dehydrogenase (11beta-HSD) is the key enzyme of glucocorticoid metabolism, which catalyzes interconversion of corticosterone and 11-dehydrocorticosterone in rat. The activity of 11beta-HSD in kidneys of rats with inherited stress-induced arterial hypertension (ISIAH) was significantly (p < 0.05) higher than that in WAG rats. The opposite was observed in the activity of liver 11beta-HSD. Under stress condition no changes in the kidney 11beta-HSD activity of both strains were observed, but the liver 11beta-HSD activity in ISIAH rats was significantly (p < 0.05) higher as compared to basal level and stressed WAG rats. It is possible that the features of the 11beta-HSD activity in ISIAH rats may reflect the hypertensive status of ISIAH rats.

• Authors: O P Cherkasova
• Journal: Biomeditsinskaia khimiia (Biomed Khim) 2006 Nov-Dec Vol. 52 Issue 6 Pg. 568-75 ISSN: 2310-6972 [Print] Russia (Federation)
• PMID: 17288248 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 11-beta-Hydroxysteroid Dehydrogenases
• 11-dehydrocorticosterone
• Corticosterone

Topics

• 11-beta-Hydroxysteroid Dehydrogenases (metabolism)
• Animals
• Corticosterone (analogs & derivatives, metabolism)
• Hypertension (enzymology, genetics)
• Kidney (enzymology)
• Liver (enzymology)
• Rats
• Rats, Inbred Strains
• Species Specificity
• Stress, Physiological (enzymology, genetics)