Heart failure has been identified as a serious international problem, in particular for aging groups, posing both an increasing number of patients on waiting lists in countries susceptible with Medicare systems and increasing financial burdens. It may be imperative to develop a marker that can identify such problems at an early stage. It is believed that certain
proteins have crucial roles in early detection of
cardiovascular disease, the number one killer in United Arab Emirates. This might be accomplished by recognition of unusual features in
protein candidates.
Phospholamban (PLB) is a 52
amino acid phosphoprotein which regulates the
calcium pump of cardiac sarcoplasmic reticulum (SR). During muscle contraction, PLB inhibits the Ca++ pump. During muscle relaxation, it can be phosphorylated, removing the inhibition and allowing Ca++ to be pumped back into SR. With the
calcium pump disrupted, the heart muscle is probably weakened, resulting in
congestive heart failure.
Interleukin 6 (IL-6) is considered as a better predictor of
heart attack in elderly people. It could serve as an early warning sign since its level increases early in the inflammatory process. Also, it has been established that
myocyte enhancer factor 2A (MEF2A) plays a vital role in the development of cardiovascular problems like
atherosclerosis and restenosis after angioplasty
inflammation. In this paper, the resonance recognition method (RRM) has been employed to determine the characteristic frequencies of the above-mentioned
proteins. It has been found that
phospholamban and
IL-6 share the same characteristic frequency, 0.3320 plusmn 0.0002 suggesting their common probable contribution to
heart failure.
Myocyte enhancer factor 2A does not share the same characteristic frequency. Hence,
phospholamban is suggested as a highly probable early marker for cardiac problem detection.