Abstract | OBJECTIVE: METHODS: After baseline measurements, the effects of renal artery stenosis (1K, 1C hypertension) were studied in groups of untreated and enalapril-treated dogs early (1-3 weeks) and later (4-6 weeks) as the hypertension developed. Both resting and open-loop haemodynamic measurements were made and the effects of acute intravenous infusions of vasopressin (0.25, 0.5 and 1.25 ng/kg per min) and phenylephrine (0.125, 0.25 and 0.50 microg/kg per min on arterial pressure, cardiac output and calculated total peripheral resistance responses were measured. RESULTS:
Renal artery stenosis induced an increase in arterial blood pressure in both groups of dogs, with similar changes in haemodynamics also observed in open-loop conditions. The slopes of arterial pressure and peripheral resistance responses to vasopressin and phenylephrine were not significantly changed in early or late hypertension, in either the untreated or enalapril-treated groups. CONCLUSIONS:
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Authors | Warwick P Anderson, Amany Shweta, Roger G Evans, Amanda J Edgley, Yi Gao |
Journal | Journal of hypertension
(J Hypertens)
Vol. 25
Issue 3
Pg. 649-62
(Mar 2007)
ISSN: 0263-6352 [Print] England |
PMID | 17278982
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Ganglionic Blockers
- Vasoconstrictor Agents
- Arginine Vasopressin
- Phenylephrine
- Enalapril
- Pentolinium Tartrate
- Captopril
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Topics |
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Animals
- Arginine Vasopressin
(pharmacology)
- Blood Pressure
(drug effects)
- Captopril
(pharmacology)
- Cardiac Output
(drug effects)
- Disease Models, Animal
- Dogs
- Enalapril
- Ganglionic Blockers
(pharmacology)
- Hypertension, Renovascular
(drug therapy, physiopathology)
- Male
- Pentolinium Tartrate
(pharmacology)
- Phenylephrine
(pharmacology)
- Vascular Resistance
(drug effects)
- Vasoconstrictor Agents
(pharmacology)
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