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Treatment of extensive cutaneous metastatic melanoma with topical diphencyprone.

Abstract
Diphencyprone is a potent contact sensitizer sometimes used to treat alopecia areata and cutaneous warts. A patient with previous primary nodular melanoma on the scalp developed extensive, confluent cutaneous metastases near the primary site, unsuitable for treatment with surgery or radiotherapy. Topical treatment with diphencyprone as a single agent resulted in regression of all lesions, and the patient remains well 18 months later. Topical immunotherapy with diphencyprone was an inexpensive and well-tolerated treatment for extensive cutaneous melanoma metastases in our patient unsuitable for other therapies.
AuthorsDiona L Damian, John F Thompson
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 56 Issue 5 Pg. 869-71 (May 2007) ISSN: 1097-6787 [Electronic] United States
PMID17276544 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Cyclopropanes
  • diphenylcyclopropenone
Topics
  • Administration, Topical
  • Aged
  • Antineoplastic Agents (administration & dosage)
  • Cyclopropanes (administration & dosage)
  • Humans
  • Male
  • Melanoma (drug therapy, secondary)
  • Neoplasm Recurrence, Local (drug therapy)
  • Skin Neoplasms (drug therapy, secondary)

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