Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-hour pH monitoring.

Abstract

OBJECTIVE:

Laryngopharyngeal reflux (LPR) is generally treated with twice-daily proton-pump inhibitor (PPI) therapy. In this study, the efficacy of esomeprazole 40 mg once-daily together with lifestyle modifications was determined by repeated 24-hour pH monitoring.

STUDY DESIGN AND SETTING:

A prospective study. Forty-nine patients with suspected LPR underwent 24-hour pH monitoring. Twenty-seven of 49 patients with measurable abnormal proximal reflux reflected by a reflux area index (RAI)>6.3 were treated with esomeprazole 40 mg every day, and a second pH study was performed.

RESULTS:

In 22 of 27 patients, everyday PPI treatment reduced the RAI. Four of 5 patients with no RAI reduction reported on symptomatic relief.

CONCLUSION:

In a considerable number of patients with suspected LPR, pH monitoring reveals no abnormal proximal reflux. Esomeprazole 40 mg every day together with lifestyle modifications could reach adequate acid suppression in a large number of patients. Symptom improvement is also reported by patients without measurable effects of therapy.

• Authors: Oliver Reichel, Jeanette Keller, Gerd Rasp, Hjalmar Hagedorn, Alexander Berghaus
• Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (Otolaryngol Head Neck Surg) Vol. 136 Issue 2 Pg. 205-10 (Feb 2007) ISSN: 0194-5998 [Print] England
• PMID: 17275540 (Publication Type: Journal Article)

Chemical References

• Enzyme Inhibitors
• Esomeprazole

Topics

• Adult
• Aged, 80 and over
• Enzyme Inhibitors (therapeutic use)
• Esomeprazole (therapeutic use)
• Female
• Fundoplication
• Humans
• Hydrogen-Ion Concentration
• Hypopharynx
• Life Style
• Male
• Middle Aged
• Monitoring, Ambulatory
• Pharyngeal Diseases (drug therapy)