HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Genetics in patients with psoriatic arthritis].

AbstractOBJECTIVES:
HLA antigens were studied in 100 Hungarian patients suffered from psoriatic arthritis. Genetic markers for the development of different clinical pattern of the disease and skin disorder were identified.
METHODS:
Determination of class I and class II antigens was performed by using microlymphocytotoxicity assay.
RESULTS:
The frequency of HLA-Cw6, HLA-B16 (and its split B-39) and HLA-B27 antigens were significantly higher in psoriatic arthritis patients than in the Hungarian general population. No connection was found between HLA-DR4, DR7, B17 antigens and psoriatic arthritis. The patients were classified according to the subgroups proposed by Gladman. The comparisons between the clinical subgroups revealed a significant association of HLA-B27 with spondylitis (Gladman 4, 5, 6, 7). There was no association between HLA DR4 and polyarticular pattern of the disease (Gladman 3, 7). Psoriasis seemed to be significantly associated only with HLA-Cw6. There was a higher frequency of HLA-B38 in psoriatic arthritis patients with erythroderma.
AuthorsKatalin Imre, Eva Koó, Magdolna Seszták, Vladimir Bosák, Olga Bitterova
JournalOrvosi hetilap (Orv Hetil) Vol. 147 Issue 50 Pg. 2415-9 (Dec 17 2006) ISSN: 0030-6002 [Print] Hungary
Vernacular TitleArthritis psoriaticaában szenvedo betegek genetikai vizsgálata.
PMID17274187 (Publication Type: English Abstract, Journal Article)
Chemical References
  • HLA-B27 Antigen
  • HLA-C Antigens
  • HLA-C*06 antigen
Topics
  • Adult
  • Aged
  • Arthritis, Psoriatic (genetics, immunology)
  • Female
  • HLA-B27 Antigen (analysis)
  • HLA-C Antigens (analysis)
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Risk Factors
  • Spondylitis (genetics, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: