Abstract | OBJECTIVES: METHODS: Regional myocardial stunning was induced in anesthetized dogs by coronary occlusion for 15 min followed by reperfusion for 3 h. Gd(3+) (500 micromol) was given intravenously in three treatment groups: [1] preischemia; [2] during ischemia; [3] after reperfusion. No Gd(3+) was given to controls (Group 4). Measures of global and regional myocardial function were assessed serially. RESULTS: Treatment with Gd(3+) prior to ischemia (Group 1) had no effects on hemodynamics or regional contraction. Coronary occlusion resulted in diastolic lengthening and paradoxical systolic bulging equally in all groups. After 3 h of reperfusion, regional systolic shortening (%) in the stunned segment was greater in Groups 1 (10.9 +/- 3.4; P = 0.02) and 2 (6.6 +/- 1.3; P = 0.047) compared with controls (-0.6 +/- 0.03). Recovery of systolic function (% of baseline shortening) after 3 h of reperfusion was similarly improved in Groups 1 (56.1 +/- 16.8; P = 0.02) and 2 (43.3 +/- 8.1; P = 0.04) compared with controls (-11.5 +/- 4.7). CONCLUSIONS:
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Authors | Alfred C Nicolosi, Chiaki S Kwok, Brent Logan |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 139
Issue 2
Pg. 286-91
(May 15 2007)
ISSN: 0022-4804 [Print] United States |
PMID | 17270216
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Dogs
- Gadolinium
(pharmacology)
- Heart
(drug effects, physiopathology)
- Myocardial Contraction
- Myocardial Ischemia
(physiopathology)
- Myocardial Reperfusion Injury
(physiopathology)
- Myocardial Stunning
(physiopathology)
- Recovery of Function
- Systole
- Time Factors
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