[Sweet's syndrome associated with squamous cell bronchial carcinoma. Neutrophilic dermatosis and non-small cell lung cancer].

Abstract

INTRODUCTION:

Sweet's syndrome, one of the neutrophilic dermatoses, is idiopathic in most cases. In 10-20% of cases it is paraneoplastic, associated with a solid tumour or haematological malignancy. An association with carcinoma of the bronchus has been only rarely described.

CASE REPORT:

We report the case of a 56 year old man who presented with Sweet's syndrome two months before the diagnosis of a squamous cell carcinoma of the bronchus. The dermatosis responded well to corticosteroids. The progress of the tumour was favourable, with stabilisation following 3 courses of chemotherapy and local radiotherapy.

DISCUSSION:

This case report updates this rare association and underlines the importance of undertaking appropriate thoracic investigations in the presence of this dermatosis. A paraneoplastic secretion of interleukin-8, GM-CSF and/or G-CSF by the bronchial tumour cells facilitating the recruitment of neutrophils, particularly in the skin, may account for the pathophysiology of this condition.

• Authors: A Van Denhove, N Freymond, S Isaac, K Marrou, B Balme, F Gormand, B Guibert, Y Pacheco, G Devouassoux
• Journal: Revue des maladies respiratoires (Rev Mal Respir) Vol. 24 Issue 1 Pg. 77-80 (Jan 2007) ISSN: 0761-8425 [Print] France
• Vernacular Title: Syndrome de Sweet révélant un carcinome bronchique épidermoïde. Cancer bronchique et dermatose neutrophilique.
• PMID: 17268370 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Bronchial Neoplasms (complications)
• Carcinoma, Non-Small-Cell Lung (complications)
• Carcinoma, Squamous Cell (complications)
• Humans
• Lung Neoplasms (complications)
• Male
• Middle Aged
• Paraneoplastic Syndromes (etiology)
• Sweet Syndrome (etiology)