Abstract | STUDY DESIGN: OBJECTIVES: To evaluate the effects of sarpogrelate hydrochloride on neurogenic pain induced by nucleus pulposus translocation and to elucidate its mechanism. SUMMARY OF BACKGROUND DATA: METHODS: The autologous nucleus pulposus was placed onto the left L4 and L5 nerve roots of 30 Sprague-Dawley rats allotted to sarpogrelate (100 mg/kg, n = 15) and control (vehicle, n = 15) treatment groups. Sarpogrelate or vehicle was administered orally once daily between days 7 and 14 after surgery. Mechanical allodynia was measured before and after treatment. The right and left nerve roots and dorsal root ganglions were isolated from 5 animals in each group to assay 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), and norepinephrine on day 5 of administration (= day 11 after surgery). RESULTS: CONCLUSIONS:
Sarpogrelate attenuated pain-related behavior induced by the nucleus pulposus in the animal model. Although further investigation is needed concerning the mechanism of action, this study supported the hypothesis that sarpogrelate is efficacious for treating the pain of lumbar disc herniation.
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Authors | Hiroshi Hashizume, Mamoru Kawakami, Munehito Yoshida, Motohiro Okada, Yoshio Enyo, Yuji Inomata |
Journal | Spine
(Spine (Phila Pa 1976))
Vol. 32
Issue 3
Pg. 315-20
(Feb 01 2007)
ISSN: 1528-1159 [Electronic] United States |
PMID | 17268262
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptor, Serotonin, 5-HT2A
- Serotonin 5-HT2 Receptor Antagonists
- Serotonin Antagonists
- Succinates
- sarpogrelate
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Topics |
- Animals
- Intervertebral Disc
(drug effects, pathology)
- Intervertebral Disc Displacement
(drug therapy, pathology)
- Lumbar Vertebrae
(drug effects, pathology)
- Pain Measurement
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Receptor, Serotonin, 5-HT2A
(physiology)
- Serotonin 5-HT2 Receptor Antagonists
- Serotonin Antagonists
(pharmacology, therapeutic use)
- Succinates
(pharmacology, therapeutic use)
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