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A comparison of medication side effect reports by panic disorder patients with and without concomitant cognitive behavior therapy.

AbstractOBJECTIVE:
The authors assessed whether adding cognitive behavior therapy (CBT) to imipramine for patients with panic disorder decreased the severity of side effects and dropouts from side effects.
METHOD:
Data were analyzed for 172 panic disorder patients who were randomly assigned to receive imipramine alone, imipramine plus CBT, or placebo. Mixed-effects models were used to assess longitudinal differences among the treatment groups with respect to side effect burden and dropout rates during the acute, maintenance, and follow-up phases of treatment.
RESULTS:
Patients treated with imipramine plus CBT experienced less severe fatigue/weakness, dry mouth, and sweating and had a lower rate of dropout due to side effects compared with those treated with imipramine only.
CONCLUSIONS:
The addition of CBT to medication treatment with imipramine was associated with less severe side effects and fewer dropouts due to perceived side effects than treatment with imipramine alone.
AuthorsSue M Marcus, Jack Gorman, M Katherine Shear, David Lewin, Jose Martinez, Susan Ray, Raymond Goetz, Serge Mosovich, Lauren Gorman, David Barlow, Scott Woods
JournalThe American journal of psychiatry (Am J Psychiatry) Vol. 164 Issue 2 Pg. 273-5 (Feb 2007) ISSN: 0002-953X [Print] United States
PMID17267790 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
Chemical References
  • Antidepressive Agents, Tricyclic
  • Placebos
  • Imipramine
Topics
  • Antidepressive Agents, Tricyclic (adverse effects, therapeutic use)
  • Cognitive Behavioral Therapy
  • Combined Modality Therapy
  • Fatigue (chemically induced)
  • Humans
  • Hyperhidrosis (chemically induced)
  • Imipramine (adverse effects, therapeutic use)
  • Panic Disorder (drug therapy, prevention & control, therapy)
  • Patient Dropouts (statistics & numerical data)
  • Placebos
  • Severity of Illness Index
  • Sweating (drug effects)
  • Xerostomia (chemically induced)

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