Variability in platelet response to antiplatelet
therapy and its clinical relevance have been well described. However, the underlying mechanisms remain unclear. It was the aim of the present study to assess whether the response to
aspirin and
clopidogrel may be influenced by the 807 C/T polymorphism of the
glycoprotein Ia (
GpIa) gene in patients with non-ST elevation
acute coronary syndrome (NSTE ACS). Six hundred one NSTE ACS patients were included in our study and were divided into three groups: CC homozygotes, CT heterozygotes ad TT homozygotes. All patients received loading doses of 600 mg
clopidogrel and 250 mg
aspirin at least 12 hours before blood samples were drawn. Post-treatment platelet reactivity was assessed by post treatment
ADP 10 microM-induced platelet aggregation (
ADP-Ag), VASP phosphorylation (PRI VASP) and
P-selectin expression. Non-response to dual antiplatelet
therapy was defined by high post-treatment platelet reactivity (HPPR=
ADP-Ag > 70%). Significant variability in the distribution of platelet parameters was observed in the overall study population. No significant difference in platelet parameters profiles was observed within patients having the same genotype, for
ADP-Ag (p=0.33), PRIVASP (p=0.72) and
P-selectin expression (p=0.37). The genotype frequencies of the 807 C/T polymorphism of the
GpIa gene were similar in responders and non-responders defined by persistent HPPR (p=0.104). In conclusion, our study did not show any influence of 807 C/T polymorphism of
GpIa gene on post-treatment platelet reactivity assessed by
ADP-Ag, PRI VASP or
P-selectin expression in 601 NSTE ACS patients.