Biologically active constituents of Centipeda minima: sesquiterpenes of potential anti-allergy activity.

Abstract

Ether, methanol and aqueous extracts of Centipeda minima (Compositae) herbs were found to have significant anti-allergy activities in passive cutaneous anaphylaxis (PCA) test. Three flavonoids, two sesquiterpene lactones and an amide were isolated from this plant material as inhibitors to induced histamine release from mast cells. The sesquiterpenes were identified as isobutyroylplenolin and senecioylplenolin by spectral investigations. The flavonoids and sesquiterpenes exhibited significant anti-allergy activity in PCA test with p.o. administration.

• Authors: J B Wu, Y T Chun, Y Ebizuka, U Sankawa
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 39 Issue 12 Pg. 3272-5 (Dec 1991) ISSN: 0009-2363 [Print] Japan
• PMID: 1726075 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Sesquiterpenes

Topics

• Animals
• Histamine Release (drug effects)
• Hypersensitivity (drug therapy)
• Male
• Mast Cells (drug effects, metabolism)
• Passive Cutaneous Anaphylaxis (drug effects)
• Plants, Medicinal (chemistry)
• Rats
• Rats, Inbred Strains
• Sesquiterpenes (isolation & purification, pharmacology)