In order to study the connection of diastolic activity of smooth muscles of blood vessels with development of
hypertension, plasma cAMP, cGMP, TXB2, 6-K-PGF1
alpha, ANP, SP were determined with radioimmunoassay, of 173
hypertension patients with Liver Yang exuberance (
LYE) 91 cases, and
Yin deficiency and Yang exuberance (YDYE) 82 cases. In addition, 228 health subjects served as control. The results showed that the levels of cAMP, cGMP and TXB2 in both
LYE and YDYE groups were higher than those in the control group, but the levels of
ANP, SP and cAMP/cGMP ratio in
LYE and YDYE groups were lower than those in the control. As to the level of 6-K-PGF1 alpha, no significant variance was found between these groups. After TCM-WM treatment, the levels of cAMP, cGMP and TXB2 in
LYE and YDYE groups got down, as compared with those in the control, adversely the levels of
ANP, SP and 6-K-PGF1 alpha in
LYE and YDYE groups turned up significantly. However the cAMP/cGMP ratio had no remarkable change between these groups. The linear regression analyses between the diastolic pressure and
ANP or SP both proved negative correlation (r = -0.36, P less than 0.05; r = -0.35, P less than 0.05). The findings indicated that the TCM-WM treatment was the most effective among the
therapies employed in the study, and that this
therapy affected the diastolic activity of smooth muscles by modulating the above factors existing in the nervous and endocrine systems of the patients with
hypertension.