Treatment of malignant glioma with high dose intra-arterial ACNU and autologous bone marrow transplantation--case report.

Abstract

A 44-year-old female with malignant astrocytoma received subtotal removal and high dose (200 mg/m2) intra-arterial 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chloroethyl)-3-nitrosourea hydrochloride (ACNU) with autologous bone marrow transplantation. Tumor remission with minimal bone marrow suppression was achieved. However, she developed severe encephalopathy and computed tomographic scans revealed a low-density area at the ACNU delivery site. She received glycerol solution to treat the brain edema and recovered completely from the encephalopathy. Intra-arterial ACNU exceeding 200 mg/m2 possibly causes neurotoxicity.

• Authors: T Fujiwara, J Yoshioka, T Ohmoto
• Journal: Neurologia medico-chirurgica (Neurol Med Chir (Tokyo)) Vol. 31 Issue 10 Pg. 654-7 (Oct 1991) ISSN: 0470-8105 [Print] Japan
• PMID: 1725815 (Publication Type: Case Reports, Journal Article)

Chemical References

• Nimustine
• Glycerol

Topics

• Adult
• Agranulocytosis (chemically induced, surgery)
• Astrocytoma (drug therapy, surgery)
• Bone Marrow Transplantation
• Brain Edema (chemically induced, drug therapy)
• Brain Neoplasms (drug therapy, surgery)
• Combined Modality Therapy
• Female
• Frontal Lobe (drug effects, surgery)
• Glycerol (therapeutic use)
• Humans
• Injections, Intra-Arterial
• Neoplasm Recurrence, Local (drug therapy, radiotherapy)
• Nimustine (administration & dosage, adverse effects, therapeutic use)
• Thrombocytopenia (chemically induced, surgery)