[Characteristics of cell membrane of B-lymphocytes in chronic lymphocytic leukemia. I. Expression of class II antigens (HLA-D)].

Abstract

Surface expression of class II antigens (HLA-D) on B lymphocytes was studied in 47 patients with chronic lymphatic leukemia (CLL) with an aid of monoclonal antibodies against monomorphic determinants of DR, DP and DQ. An association was found between progression of disease and gradual loss of those markers, especially DP and DQ.

• Authors: A Pluta, A Górski, M Nowaczyk
• Journal: Polskie Archiwum Medycyny Wewnetrznej (Pol Arch Med Wewn) Vol. 86 Issue 3 Pg. 149-53 (Sep 1991) Poland
• Vernacular Title: Charakterystyka błonowa limfocytów B w przewlekłej białaczce limfatycznej. I. Ekspresja antygenów klasy II (HLA-D).
• PMID: 1725558 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Epitopes
• HLA-DP Antigens
• HLA-DQ Antigens
• HLA-DR Antigens

Topics

• Adult
• Aged
• Antibodies, Monoclonal (immunology)
• B-Lymphocytes (immunology, ultrastructure)
• Cell Membrane (immunology)
• Epitopes (analysis, immunology)
• Female
• HLA-DP Antigens (analysis, immunology)
• HLA-DQ Antigens (analysis, immunology)
• HLA-DR Antigens (analysis, immunology)
• Humans
• Leukemia, Lymphocytic, Chronic, B-Cell (immunology, pathology)
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis