Abstract | STUDY OBJECTIVE: DESIGN: Retrospective, population-based, epidemiologic study. DATA SOURCE: PharMetrics database. SUBJECTS: Females aged 15-45 years in the PharMetrics database who had filled at least one prescription for the Ortho EVRA contraceptive patch or a norgestimate OC between April 1, 2002, and March 31, 2005. MEASUREMENTS AND MAIN RESULTS: Incidence rates and 95% confidence intervals (CI) were estimated for the outcomes of ischemic stroke and acute myocardial infarction by exposure. Crude incidence rates of ischemic stroke among users of the patch and users of norgestimate OCs were 13.6/100,000 woman-years (95% CI 5.9-26.8) and 11.3/100,000 woman-years (95% CI 5.4-20.8), respectively. The crude incidence rate of acute myocardial infarction was 1.7/100,000 woman-years (95% CI 0.04-9.5) in current patch users and 7.9/100,000 woman-years (95% CI 3.2-16.3) in current users of norgestimate OCs. Incidence rate ratios (IRRs) were estimated for the outcomes by comparing data for users of the patch and users of a norgestimate OC. The IRR for stroke was 1.2 (95% CI 0.41-3.4) and for acute myocardial infarction was 0.2 (95% CI 0.004-1.7). CONCLUSION:
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Authors | Susan S Jick, Hershel Jick |
Journal | Pharmacotherapy
(Pharmacotherapy)
Vol. 27
Issue 2
Pg. 218-20
(Feb 2007)
ISSN: 0277-0008 [Print] United States |
PMID | 17253912
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contraceptive Agents
- Contraceptives, Oral
- Norgestrel
- norgestimate
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Brain Ischemia
(epidemiology, etiology)
- Contraceptive Agents
(administration & dosage, adverse effects)
- Contraceptives, Oral
- Female
- Humans
- Incidence
- Middle Aged
- Myocardial Infarction
(chemically induced, epidemiology)
- Norgestrel
(adverse effects, analogs & derivatives)
- Retrospective Studies
- Stroke
(epidemiology, etiology)
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