Sclerokeratitis and facial skin lesions: a case report of pyoderma gangrenosum and its response to dapsone therapy.

Abstract

PURPOSE:

This documents the evaluation and management of a patient with an unusual destructive external ocular disorder in the context of progressively disfiguring dermatitis.

METHODS:

Observational case report including ophthalmologic examination with conjunctival and corneal scraping, radiologic studies of the sinuses and chest, skin, conjunctival, and scleral biopsies, and serologic studies.

RESULTS:

Biopsies, cultures, and serologic testing led to the conclusion that the patient had pyoderma gangrenosum. Therapy with dapsone resulted in preservation of vision and resolution of the oculocutaneous inflammation.

CONCLUSIONS:

Pyoderma gangrenosum is a rare autoimmune disorder that can affect the eye. Biopsy of affected tissue is the key to diagnosis. Immunomodulating therapy can be a useful adjunct to the traditional steroid therapy.

• Authors: Laura A Teasley, C Stephen Foster, Stefanos Baltatzis
• Journal: Cornea (Cornea) Vol. 26 Issue 2 Pg. 215-9 (Feb 2007) ISSN: 0277-3740 [Print] United States
• PMID: 17251816 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Dapsone

Topics

• Adult
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Biopsy
• Dapsone (therapeutic use)
• Face
• Female
• Follow-Up Studies
• Humans
• Keratitis (drug therapy, etiology, pathology)
• Pyoderma Gangrenosum (complications, drug therapy, pathology)
• Scleritis (drug therapy, etiology, pathology)
• Severity of Illness Index