Efficacy and tolerability of cefixime in otitis media. A multicentre study in over 25,000 children.

Abstract

A large scale multicentre clinical study was undertaken to assess the efficacy and tolerability of cefixime in the treatment of acute otitis media in children. A total of 25,863 evaluable children with acute otitis media received cefixime 8 mg/kg once daily for at least 10 days. At the end of treatment, 86% of patients were considered to be either cured or improved. These results are consistent with those achieved with cefixime in controlled clinical trials. Adverse effects were reported in 11.5% of patients, but were judged to be related to cefixime therapy in only 9.4% of patients. The results of this study demonstrate that cefixime is an effective and well tolerated treatment for acute otitis media in children.

• Authors: D H Wu
• Journal: Drugs (Drugs) Vol. 42 Suppl 4 Pg. 30-2 ( 1991) ISSN: 0012-6667 [Print] New Zealand
• PMID: 1725152 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Cefixime
• Cefotaxime

Topics

• Acute Disease
• Cefixime
• Cefotaxime (analogs & derivatives, therapeutic use)
• Child
• Child, Preschool
• Drug Tolerance
• Female
• Humans
• Infant
• Infant, Newborn
• Male
• Otitis Media (drug therapy)