HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cerebrospinal fluid tau, phospho-tau181 and beta-amyloid1-42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease.

Abstract
The aim of the present study was the quantitation of total tau protein (tau(T)), tau phosphorylated at threonine 181 (tau(P-181)) and beta-amyloid(1-42) (Abeta42) in the cerebrospinal fluid (CSF) of patients with idiopathic normal pressure hydrocephalus (iNPH), Alzheimer's disease (AD) and controls. Double sandwich ELISAs (Innogenetics) were used for the measurements. Total tau was significantly increased in iNPH and highly increased in AD as compared with the control group, whilst Abeta42 was decreased in both diseases. CSF tau(P-181) levels were significantly increased only in AD, but not in iNPH as compared with the controls. A cut-off level for tau(T) at 300 pg/ml, successfully discriminated AD from normal aging with a 95.8% specificity and 91% sensitivity; whilst the tau(P-181)/tau(T) ratio (cut-off value 0.169) was more specific (100%) but less sensitive (92.5%). For the discrimination of iNPH from AD tau(T) achieved low specificity (77.8%) but high sensitivity (92.5%), whilst tau(P-181) (cut-off value 47.4) was both sensitive and specific (88.7% and 86.7% respectively) for the discrimination of these disorders. The present study, despite being clinical, supports the notion that CSF tau(P-181) alone or in combination with tau(T) may be a useful marker in the discrimination of iNPH from AD.
AuthorsE N Kapaki, G P Paraskevas, N G Tzerakis, C Sfagos, A Seretis, E Kararizou, D Vassilopoulos
JournalEuropean journal of neurology (Eur J Neurol) Vol. 14 Issue 2 Pg. 168-73 (Feb 2007) ISSN: 1468-1331 [Electronic] England
PMID17250725 (Publication Type: Journal Article)
Chemical References
  • Amyloid beta-Peptides
  • Biomarkers
  • Peptide Fragments
  • Phosphoproteins
  • amyloid beta-protein (1-42)
  • tau Proteins
  • Threonine
Topics
  • Aged
  • Aging (cerebrospinal fluid)
  • Alzheimer Disease (cerebrospinal fluid, diagnosis)
  • Amyloid beta-Peptides (cerebrospinal fluid)
  • Biomarkers (cerebrospinal fluid)
  • Diagnosis, Differential
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Hydrocephalus, Normal Pressure (cerebrospinal fluid, diagnosis)
  • Male
  • Middle Aged
  • Peptide Fragments (cerebrospinal fluid)
  • Phosphoproteins (cerebrospinal fluid, metabolism)
  • Phosphorylation
  • Sensitivity and Specificity
  • Threonine
  • tau Proteins (cerebrospinal fluid, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: