Clinical and molecular cytogenetic characteristics of dic(9;20) in adult acute lymphoblastic leukemia: a case report of three patients.

Abstract

Dicentric (9;20) [dic(9;20)] is a rare recurring chromosome abnormality in leukemia patients. In this study, we report three adult patients with acute lymphoblastic leukemia (ALL) with dic(9;20) anomaly. All three patients were diagnosed as cluster of differentiation 10 (CD10) positive B cell ALL, achieved complete remission after induction chemotherapy, and died of leukemia relapse within 1 year after diagnosis. Specimens for chromosome analysis were prepared by direct method and/or short-time culture of bone marrow cells. Karyotyping was performed by R-banding technique. Dual-color fluorescence in situ hybridization (FISH) was performed using chromosome 9 and chromosome 20-specific centromeric probes. Karyotype analysis showed that all three patients had dic(9;20)(p11-13;q11), in which the dicentric nature of the derived chromosome was confirmed by interphase FISH. Dicentric (9;20)(p11-13;q11) may be specifically associated with ALL, and monosomy 20 may be a pointer to dic(9;20) in ALL. The prognostic significance of dic(9;20) in adult patients with ALL remains to be determined.

• Authors: Xianmin Song, Shenglan Gong, Jianmin Yang, Jianmin Wang
• Journal: Annals of hematology (Ann Hematol) Vol. 86 Issue 5 Pg. 347-51 (May 2007) ISSN: 0939-5555 [Print] Germany
• PMID: 17245591 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Burkitt Lymphoma (genetics)
• Chromosome Aberrations
• Chromosomes, Human, Pair 20
• Chromosomes, Human, Pair 9
• Fatal Outcome
• Female
• Humans
• In Situ Hybridization, Fluorescence
• Male
• Middle Aged
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics)
• Translocation, Genetic