Antithrombin and protein C in systemic inflammatory response syndrome.

Abstract

Coronary artery bypass grafting with cardiopulmonary bypass can induce systemic inflammatory response syndrome. To assess the prevalence of preoperative antithrombin and protein C deficiencies in relation to the incidence of this syndrome, antithrombin and protein C levels were measured in 130 patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. Systemic inflammatory response syndrome developed in 36 (27.7%) patients who were predominantly male, had a lower EuroSCORE, longer cardiopulmonary bypass time, higher pre-bypass temperature, and shorter activated coagulation time. Logistic regression showed that predictive factors included bypass duration and pre-bypass temperature; however, low antithrombin levels appeared to be a negative predictive factor. Antithrombin levels were < 80% in 33.8% of patients, and 11.6% had protein C levels < 80%. Postoperative antithrombin and protein C deficiencies are not uncommon in adults undergoing cardiac surgery with cardiopulmonary bypass, but detection of these deficits did not identify patients at increased risk of systemic inflammatory response syndrome.

• Authors: Islam Massad, Hamdi Abu-Ali, Christine Biron-Andreani, Marie-Christine Picot, Philippe Trinh-Duc
• Journal: Asian cardiovascular & thoracic annals (Asian Cardiovasc Thorac Ann) Vol. 15 Issue 1 Pg. 39-44 (Jan 2007) ISSN: 1816-5370 [Electronic] England
• PMID: 17244921 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antithrombins
• Biomarkers
• Protein C

Topics

• Adult
• Antithrombins (analysis, deficiency)
• Biomarkers (blood)
• Blood Coagulation Disorders (epidemiology)
• Cardiopulmonary Bypass (adverse effects)
• Coronary Artery Bypass (adverse effects)
• Female
• Humans
• Male
• Prevalence
• Protein C (analysis)
• Protein C Deficiency (blood, epidemiology)
• Systemic Inflammatory Response Syndrome (blood, etiology)