Abstract | CONTEXT: OBJECTIVE: The objective was to examine the association between endogenous sex hormones and glucose tolerance in postmenopausal women. DESIGN, SETTING, AND PARTICIPANTS: MAIN OUTCOME MEASURES: RESULTS: Increasing quartiles of bioavailable T and E2 and decreasing quartiles of SHBG were associated with significantly increased odds of IFG and diabetes (all P for trend<0.001). Except for the association of bioavailable T with diabetes, the other associations persisted after multivariable adjustment. Although higher dehydroepiandrostenedione ( DHEA) was associated with greater odds of IFG (P for trend=0.02), it was not associated with diabetes. Of 1100 women with normal glucose tolerance, E2 and DHEA were positively associated, and SHBG was inversely associated with HOMA-IR (all P<0.001) after multivariable adjustment. Bioavailable T was associated with HOMA-IR (P<0.001), but not fasting glucose. CONCLUSION: Of postmenopausal women, endogenous bioavailable T, E2, and DHEA were positively associated and SHBG was negatively associated with insulin resistance.
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Authors | Sherita Hill Golden, Adrian S Dobs, Dhananjay Vaidya, Moyses Szklo, Susan Gapstur, Peter Kopp, Kiang Liu, Pamela Ouyang |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 92
Issue 4
Pg. 1289-95
(Apr 2007)
ISSN: 0021-972X [Print] United States |
PMID | 17244779
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Testosterone
- Estradiol
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Topics |
- Aged
- Aged, 80 and over
- Blood Glucose
(metabolism)
- Body Mass Index
- Body Size
- Cross-Sectional Studies
- Estradiol
(blood)
- Female
- Glucose Intolerance
(epidemiology)
- Glucose Tolerance Test
- Humans
- Middle Aged
- Postmenopause
- Racial Groups
- Testosterone
(blood)
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