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Investigational treatments for postoperative surgical site infections.

Abstract
Surgical site infections rank third among nosocomial infections, representing a global threat, associated with the emergence of multi-drug-resistant bacteria. The pharmaceutical industry has recently curtailed developmental programmes; however, the need for new compounds is extremely important. This article reviews new antimicrobials and immunointerventional targets for their potential to treat surgical site infections in comparison with recently licensed compounds. Daptomycin, dalbavancin, oritavancin, telavancin, iclaprim and ranbezolid seem to be promising agents against infections caused by Gram-positive pathogens and effectively address the present problems of multi-resistance in Gram-positive infections. Peptide deformylase inhibitors and immunostimulating agents open new perspectives in this field; however, very few compounds targeting Gram-negative problematic pathogens are in the pipeline of the future. Tigecycline (recently marketed) ceftobiprole, ceftaroline and doripenem seem to possess an extended anti-Gram-positive and -negative spectrum. Among these compounds, only doripenem demonstrates activity against Pseudomonas aeruginosa, for which there is a clear unmet need for new compounds, focusing on new targets.
AuthorsGaryphallia Poulakou, Helen Giamarellou
JournalExpert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 16 Issue 2 Pg. 137-55 (Feb 2007) ISSN: 1744-7658 [Electronic] England
PMID17243935 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Infective Agents
  • Drugs, Investigational
Topics
  • Animals
  • Anti-Infective Agents (therapeutic use)
  • Bacterial Infections (drug therapy, epidemiology, prevention & control)
  • Drug Resistance, Microbial (physiology)
  • Drugs, Investigational (therapeutic use)
  • Humans
  • Surgical Wound Infection (drug therapy, epidemiology, prevention & control)

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