Abstract | PURPOSE: METHODS: We used polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), to analyze XRCC1-Arg399Gln and XPD -Lys751Gln polymorphisms in 144 patients with POAG and in 121 disease-free controls, who were of a similar age. RESULTS: There was no significant difference in the genotype distribution between POAG patients and controls for each polymorphism (p>0.05). Allele frequencies were also not statistically different between the groups (p=0.46; OR: 0.77; 95% CI:0.42-1.43 for XRCC1 399Gln and p=0.88; OR: 0.92 95% CI: 0.50-1.67 for XPD 751Gln). CONCLUSIONS: Polymorphisms in XPD codon 751 and XRCC1 codon 399 were not associated with risk of POAG in a sample of Turkish patients.
|
Authors | Mehmet Güven, Mustafa Unal, Bahadir Batar, Ebru Eroğlu, Kazim Devarnoğlu, Nevbahar Tamçelik, Didar Uçar, Ahmet Sarici |
Journal | Molecular vision
(Mol Vis)
Vol. 13
Pg. 12-7
(Jan 05 2007)
ISSN: 1090-0535 [Electronic] United States |
PMID | 17242676
(Publication Type: Journal Article)
|
Chemical References |
- DNA-Binding Proteins
- X-ray Repair Cross Complementing Protein 1
- XRCC1 protein, human
- Xeroderma Pigmentosum Group D Protein
- ERCC2 protein, human
|
Topics |
- Aged
- Case-Control Studies
- DNA Repair
(genetics)
- DNA-Binding Proteins
(genetics)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Glaucoma, Open-Angle
(genetics)
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Turkey
- X-ray Repair Cross Complementing Protein 1
- Xeroderma Pigmentosum Group D Protein
(genetics)
|