Abstract | BACKGROUND: OBJECTIVE: To present the radiologic findings of a patient on long-term, low-dose acitretin and etretinate and to review the literature on the radiologic evidence of skeletal side effects during retinoid therapy. METHODS: Case report and literature search. RESULTS: A patient on low-dose acitretin had no significant radiologic abnormalities associated with retinoid use after 9 years of treatment. A review of the literature revealed conflicting reports on the incidence of radiologic abnormalities in patients on retinoid treatment. CONCLUSION: The evidence to date does not substantiate a clear link between radiologic skeletal abnormalities and long-term, low-dose acitretin or etretinate therapy.
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Authors | Caroline P Halverstam, Joshua Zeichner, Mark Lebwohl |
Journal | Journal of cutaneous medicine and surgery
(J Cutan Med Surg)
2006 Nov-Dec
Vol. 10
Issue 6
Pg. 291-9
ISSN: 1203-4754 [Print] United States |
PMID | 17241599
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Adrenal Cortex Hormones
- Keratolytic Agents
- Etretinate
- Acitretin
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Topics |
- Acitretin
(adverse effects, therapeutic use)
- Administration, Cutaneous
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Adult
- Aged
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Etretinate
(adverse effects, therapeutic use)
- Female
- Humans
- Keratolytic Agents
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Psoriasis
(drug therapy)
- Radiography
- Spinal Diseases
(chemically induced, diagnostic imaging)
- Treatment Outcome
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