Is Her-2/neu expressed in nonepithelial ovarian malignancies?

Abstract

OBJECTIVE:

The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies.

STUDY DESIGN:

Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu.

RESULTS:

Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined.

CONCLUSION:

Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.

• Authors: Joseph Menczer, Letizia Schreiber, Bernard Czernobilsky, Esther Berger, Abraham Golan, Tally Levy
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 196 Issue 1 Pg. 79.e1-4 (Jan 2007) ISSN: 1097-6868 [Electronic] United States
• PMID: 17240244 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Child
• Female
• Gene Expression Regulation, Neoplastic
• Genes, erbB-2 (genetics)
• Granulosa Cell Tumor (metabolism)
• Humans
• Middle Aged
• Neoplasms, Germ Cell and Embryonal (genetics)
• Ovarian Neoplasms (metabolism)