FDG uptake, glucose transporter type 1, and Ki-67 expressions in non-small-cell lung cancer: correlations and prognostic values.

Abstract

PURPOSE:

FDG uptake mediated by glucose transporter type 1 (Glut-1) and tumor proliferative activity assessed by Ki-67 expression provide prognostic information in patients with non-small-cell lung cancer (NSCLC). Here, we compared the prognostic significances of FDG uptake, and of Glut-1 and Ki-67 expressions in patients with NSCLC.

METHODS:

NSCLC patients (n=53, F:M=16:37, age 61.9+/-12.1 years) who underwent curative resection after FDG-PET were enrolled. Thirty-one patients had stage I, 15 stage II, and 7 stage III disease. Patients were treated by surgery only (n=12), surgery plus adjuvant oral chemotherapy (n=32), or surgery plus adjuvant intravenous chemo- or radio-therapy (n=9). Maximum standardized FDG uptake values (maxSUV), and the Glut-1 and Ki-67 expressions of resected tumors were analyzed for correlations and relations with tumor recurrence. The median follow-up duration was 15 months.

RESULTS:

Thirteen (24.5%) of the 53 patients experienced recurrence during a median follow-up of 8 months and significant correlations were found between maxSUV, Glut-1, and Ki-67 expressions (r=0.48-0.79, p<0.001). Univariate analysis revealed that disease-free survival (DFS) was significantly correlated with maxSUV (<7 versus > or =7, p=0.001), % Ki-67 expression (<25% versus > or =25%, p=0.047), tumor size (<3 cm versus > or =3 cm, p=0.027), and tumor cell differentiation (well/moderate versus poor, p=0.011). However, multivariate Cox proportional analysis identified maxSUV as the only determinant of DFS (p=0.005). Patients with a maxSUV of > or =7 (n=14) had a significantly lower 1-year DFS rate (57.1%) than those with a maxSUV of <7 (n=39, 89.7%).

CONCLUSION:

FDG uptake is more valuable than Glut-1 or Ki-67 expression in terms of predicting prognosis in patients with resected NSCLC.

• Authors: Xuan Canh Nguyen, Won Woo Lee, Jin-Haeng Chung, So Yeon Park, Sook Whan Sung, Yu Kyeong Kim, Young So, Dong Soo Lee, June-Key Chung, Myung Chul Lee, Sang Eun Kim
• Journal: European journal of radiology (Eur J Radiol) Vol. 62 Issue 2 Pg. 214-9 (May 2007) ISSN: 0720-048X [Print] Ireland
• PMID: 17239556 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Glucose Transporter Type 1
• Ki-67 Antigen
• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• Aged
• Analysis of Variance
• Biomarkers, Tumor (metabolism)
• Carcinoma, Non-Small-Cell Lung (diagnosis, diagnostic imaging, metabolism, pathology)
• Disease-Free Survival
• Female
• Fluorodeoxyglucose F18 (metabolism)
• Follow-Up Studies
• Glucose Transporter Type 1 (metabolism)
• Humans
• Ki-67 Antigen (metabolism)
• Lung Neoplasms (diagnosis, diagnostic imaging, metabolism, secondary)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diagnosis, metabolism)
• Neoplasm Staging
• Positron-Emission Tomography
• Predictive Value of Tests
• Prognosis
• Proportional Hazards Models
• Radiopharmaceuticals (metabolism)
• Retrospective Studies