Nitazoxanide or CD3+/CD4+ lymphocytes for recovery from severe Cryptosporidium infection after allogeneic bone marrow transplant?

We describe a case of Cryptosporidium infection occurring in a child after allogeneic SCT for acute non-lymphoblastic leukemia. This patient presented an intestinal, biliar, and pancreatic Cryptosporidium disease associated with an intestinal aGvHD. The increase in CD3+/CD4+ cells secondary to the reduction of steroid therapy associated with the improvement of aGvHD and the use of antiparasitic treatments (especially nitazoxanide) improved the infection-related symptoms and led to a complete clearance of the Cryptosporidium.
AuthorsM Faraci, B Cappelli, G Morreale, E Lanino, C Moroni, R Bandettini, M P Terranova, D Di Martino, C Coccia, E Castagnola
JournalPediatric transplantation (Pediatr Transplant) Vol. 11 Issue 1 Pg. 113-6 (Feb 2007) ISSN: 1397-3142 [Print] Denmark
PMID17239134 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, CD
  • Antigens, CD3
  • Antiparasitic Agents
  • Thiazoles
  • nitazoxanide
  • Animals
  • Antigens, CD (blood)
  • Antigens, CD3 (blood)
  • Antiparasitic Agents (therapeutic use)
  • Biopsy
  • CD4-Positive T-Lymphocytes (transplantation)
  • Child
  • Colon (parasitology, pathology)
  • Cryptosporidiosis (drug therapy, therapy)
  • Cryptosporidium (isolation & purification)
  • Humans
  • Leukemia, Myeloid, Acute (therapy)
  • Lymphocyte Transfusion
  • Male
  • Stem Cell Transplantation
  • Thiazoles (therapeutic use)
  • Transplantation, Homologous

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