Comparison of the effects of latanoprost and travoprost on intraocular pressure in chronic angle-closure glaucoma.

Abstract

PURPOSE:

The aim of this study was to compare the intraocular pressure (IOP)-lowering effect of latanoprost and travoprost as primary therapy in patients with chronic angle-closure glaucoma (CACG) after peripheral iridotomy.

METHODS:

Seventy-three (73) CACG patients with IOP>19 mmHg after peripheral iridotomy and without previous antiglaucoma medication were consecutively recruited. CACG was defined as the presence of chronically elevated IOP, glaucomatous optic neuropathy, and a corresponding visual field defect in eyes with occludable angle and peripheral anterior synechiae on gonioscopy. Patients were randomly assigned to 2 groups, based on daily treatment with either latanoprost 0.005% or travoprost 0.004% in the evening for 12 weeks. The IOP was measured at 9 AM and 4 PM at baseline and at 4, 8, and 12 weeks. Between-group differences in mean diurnal IOP and IOP reduction were analyzed.

RESULTS:

After 12 weeks of treatment, mean IOP for both the latanoprost and travoprost groups was significantly reduced, when compared to the baseline IOP (from 21.3+/-1.8 mmHg to 16.0+/-2.3 mmHg and 21.7+/-1.7 to 16.7+/-2.2 mmHg; P<0.001 for both). There was no significant difference in IOP reduction between the 2 treatment groups (P=0.19). At 4 and 8 weeks, the IOP changes from the baseline were statistically significant at all time points for both drugs (all P<0.001).

CONCLUSIONS:

Both latanoprost and travoprost significantly reduced IOP in our sample of CACG patients after peripheral iridotomy.

• Authors: Mei-Ju Chen, Yen-Cheng Chen, Ching-Kuang Chou, Wen-Ming Hsu
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 22 Issue 6 Pg. 449-54 (Dec 2006) ISSN: 1080-7683 [Print] United States
• PMID: 17238812 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antihypertensive Agents
• Prostaglandins F, Synthetic
• Cloprostenol
• Latanoprost
• Travoprost

Topics

• Aged
• Antihypertensive Agents (administration & dosage, therapeutic use)
• Chronic Disease
• Cloprostenol (administration & dosage, analogs & derivatives, therapeutic use)
• Female
• Glaucoma, Angle-Closure (drug therapy, surgery)
• Humans
• Intraocular Pressure (drug effects)
• Iridectomy
• Laser Therapy
• Latanoprost
• Male
• Prospective Studies
• Prostaglandins F, Synthetic (administration & dosage, therapeutic use)
• Travoprost
• Treatment Outcome