Abstract | BACKGROUND: METHODS: By using data from a community-based, case-control study of incident, sporadic colorectal adenoma that included 162 cases and 211 controls, the authors constructed multiple logistic regression models to estimate the odds ratios (OR) and 95% confidence intervals (95% CI) of colorectal adenoma after adjusting for potential confounders. RESULTS: Overall, there were no significant associations of the 2 5-LOX polymorphisms with the risk of colorectal adenoma. However, there was an inverse association between the Arg261Gln polymorphism in 12-LOX and colorectal adenoma (OR, 0.63; 95% CI, 0.40-1.00). A significant interaction also was observed between the 12-LOX polymorphism (Arg261Gln) and the use of nonsteroidal anti-inflammatory drugs (P(interaction) = .02). CONCLUSIONS: The current results suggested that polymorphisms of LOX genes may act independently or with other factors to affect the risk of colorectal adenoma. Further studies will be needed to confirm these findings. Cancer 2007 (c) 2007 American Cancer Society.
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Authors | Zhihong Gong, James R Hebert, Roberd M Bostick, Zonglin Deng, Thomas G Hurley, Dan A Dixon, Daniela Nitcheva, Dawen Xie |
Journal | Cancer
(Cancer)
Vol. 109
Issue 5
Pg. 849-57
(Mar 01 2007)
ISSN: 0008-543X [Print] United States |
PMID | 17236225
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Arachidonate 12-Lipoxygenase
- Arachidonate 5-Lipoxygenase
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Topics |
- Adenoma
(genetics)
- Adult
- Aged
- Arachidonate 12-Lipoxygenase
(genetics)
- Arachidonate 5-Lipoxygenase
(genetics)
- Colorectal Neoplasms
(genetics)
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Risk Factors
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