Abstract | OBJECTIVES: STUDY DESIGN: Twenty-nine consecutive 22q11DS patients (mean age 12.6 years) and matched healthy control subjects were clinically examined, and stimulated saliva samples were collected. RESULTS: Patients with 22q11DS had impaired salivary secretion rate (P < .01) and buffer capacity (P < .05), higher numbers of cariogenic bacteria (P < .01), increased saliva protein concentrations (P < .001), and reduced output of electrolytes (P < .001-.05) compared with control subjects. A correlation between concentration in serum and saliva was found only for IgA (r = .622; P < .01). CONCLUSIONS: Different salivary components were affected in patients with 22q11DS, which may explain the increased caries risk seen in these patients.
|
Authors | Gunilla Klingberg, Peter Lingström, Sólveig Oskarsdóttir, Vanda Friman, Eva Bohman, Anette Carlén |
Journal | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod)
Vol. 103
Issue 4
Pg. 497-504
(Apr 2007)
ISSN: 1528-395X [Electronic] United States |
PMID | 17234437
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Immunoglobulin A
- Salivary Proteins and Peptides
|
Topics |
- Adolescent
- Adult
- Case-Control Studies
- Child
- Child, Preschool
- Chromosome Deletion
- Chromosomes, Human, Pair 22
(genetics)
- Dental Caries
(blood, microbiology)
- Female
- Humans
- Immunoglobulin A
(analysis)
- Male
- Saliva
(chemistry, metabolism)
- Salivary Proteins and Peptides
(analysis)
- Salivation
- Statistics, Nonparametric
- Syndrome
|