Abstract | UNLABELLED: INTRODUCTION: MATERIALS AND METHODS: RESULTS:
Pamidronate therapy, given intravenously every 6 months at a dose of 180 mg in adults, relieved bone pain, decreased bone resorption, and improved the radiological aspect (filling of lytic lesions and/or thickening of cortices) in approximately 50% of patients. BMD in affected sites was also significantly increased after pamidronate treatment. Those results have been obtained only in open studies, without controls, by several research groups. In a series of nine patients on long-term pamidronate treatment, but resisting to this medication and switched to intravenous zoledronic acid, no substantial improvement was observed. There is some biological rationale supporting the use of calcium and vitamin D in patients with deficiency to improve FD lesions by limiting secondary hyperparathyroidism. Phosphorus supplementation may prevent mineralization defects in those patients who have both FD and renal phosphate wasting. However, we are lacking clinical evidence for the efficacy of such supplements. CONCLUSIONS:
Bisphosphonate treatment reduces increased osteoclastic activity in FD and probably improves bone pain, but their use should be better studied in randomized controlled trials.
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Authors | Roland D Chapurlat |
Journal | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
(J Bone Miner Res)
Vol. 21 Suppl 2
Pg. P114-9
(Dec 2006)
ISSN: 0884-0431 [Print] United States |
PMID | 17228999
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Child
- Child, Preschool
- Diphosphonates
(therapeutic use)
- Female
- Fibrous Dysplasia of Bone
(diagnostic imaging, drug therapy)
- Humans
- Infant
- Male
- Middle Aged
- Radiography
- Treatment Outcome
- Vitamin D
(administration & dosage, therapeutic use)
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