Abstract | BACKGROUND: Oil-based matrices enriched with plant stanol esters lower serum LDL cholesterol. The effects of low-fat milk products have been less thoroughly examined. AIM OF THE STUDY: To evaluate the effect of three less explored low-fat milk products enriched with plant stanol esters on serum lipid concentrations in subjects with mild or moderate hypercholesterolemia. METHODS: A meta-analysis of four unpublished sub-studies (yoghurt, yoghurt single-shot drink: Studies I and II, or milk). All the substudies were randomized, placebo-controlled, double-blind and had a parallel-group design. They were carried out in order to evaluate the effect of low-fat milk products enriched with plant stanol esters on serum lipid concentration. Each stanol- ester-enriched milk product provided 2 g of stanols per day, and in each study the intervention period was 5 weeks. A total of 199 hypercholesterolemic subjects completed the studies. RESULTS: The pooled treatment difference in total cholesterol was -3.8% (95% CI -6.0 to -1.7, p < 0.001) when stanol was compared to placebo. In LDL cholesterol, the pooled treatment difference was -4.9% (95% CI -7.8 to -1.8, p = 0.002). There were no significant differences between the groups in pooled HDL cholesterol or triacylglycerol concentrations. The results tended to be more pronounced when we were certain that the yoghurt single-shot drink was ingested with lunch, and when the baseline LDL-cholesterol concentration was > or = 3.5 mmol/l. CONCLUSIONS:
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Authors | Leena Seppo, Tiina Jauhiainen, Riikka Nevala, Tuija Poussa, Riitta Korpela |
Journal | European journal of nutrition
(Eur J Nutr)
Vol. 46
Issue 2
Pg. 111-7
(Mar 2007)
ISSN: 1436-6207 [Print] Germany |
PMID | 17225918
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticholesteremic Agents
- Cholesterol, HDL
- Cholesterol, LDL
- Sitosterols
- plant stanol ester
- Cholesterol
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Topics |
- Adult
- Aged
- Animals
- Anticholesteremic Agents
(therapeutic use)
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Dairy Products
- Diet, Fat-Restricted
- Double-Blind Method
- Female
- Food, Fortified
- Humans
- Hypercholesterolemia
(blood, drug therapy)
- Lipid Metabolism
(drug effects)
- Male
- Middle Aged
- Milk
(chemistry)
- Sitosterols
(therapeutic use)
- Treatment Outcome
- Yogurt
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