Abstract | OBJECTIVE: In recent years, the assessment of the plasma aldosterone-to- renin ratio (ARR) has become a most effectively and commonly used method for screening primary aldosteronism from hypertensive patients. It is known that there is a large variance in ARR value between races and ARR is affected by many factors, such as drugs, posture and serum potassium etc. The objective of this study is to establish the threshold of ARR for screening primary aldosteronism in Chinese hypertensive patients. METHODS: RESULTS: ARR was 100.00+/-48.65 (14.19-285.16) pg/ml vs ngxml-1xh-1 in patients with essential hypertension and 699.33+/-213.33 (185.8-2150) pg/ml vs ngxml-1xh-1 in patients with adenoma/ hyperplasia. ARR value was greater than 240 in 42 out of 45 patients (93.3%) with adenoma/ hyperplasia and was less than 240 in 59 out of 65 (90.7%) patients with essential hypertension. We used ARR 240 as the cut-off threshold for screening primary aldosteronism in another 178 hypertensive patients and ARR was greater than 240 in all 15 patients with confirmed primary aldosteronism. CONCLUSION: It is suitable to use upright ARR 240 as a cut-off threshold for screening primary aldosteronism in Chinese hypertensive patients.
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Authors | Shao-xing Chen, Yue-ling Du, Jin Zhang, Yan-chun Gong, Ya-rong Hu, Shao-li Chu, Qing-bo He, Yan-yan Song, Ding-liang Zhu |
Journal | Zhonghua xin xue guan bing za zhi
(Zhonghua Xin Xue Guan Bing Za Zhi)
Vol. 34
Issue 10
Pg. 868-72
(Oct 2006)
ISSN: 0253-3758 [Print] China |
PMID | 17217708
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aldosterone
- Renin
- Potassium
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Topics |
- Adult
- Aged
- Aldosterone
(blood)
- China
(epidemiology)
- Clinical Chemistry Tests
(statistics & numerical data)
- Female
- Humans
- Hyperaldosteronism
(diagnosis, epidemiology)
- Hypertension
(complications, epidemiology)
- Male
- Mass Screening
- Middle Aged
- Potassium
(blood)
- Reference Values
- Renin
(blood)
- Renin-Angiotensin System
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