Monosomy 7 as the sole abnormality of an acute basophilic leukemia.

Abstract

We report the case of a 72-year-old man who had the very rare disease acute basophilic leukemia with the sole chromosomal finding of a monosomy 7. Most nuclear cells in the peripheral blood and bone marrow samples were either basophils or blasts. The blasts showed negative reaction with myeloperoxidase, periodic acid Schiff, chloroacetate esterase, alpha-naphthyl butyrate esterase, acid phosphatase, and Sudan black B. Metachromatic features of the blasts, however, were observed with toluidine blue stain. Electron microscopic evaluation showed the typical ultrastructure, with basophil and immature mast cell granules. Cytogenetic study revealed monosomy 7 in all metaphase cells, and this finding was confirmed by fluorescence in situ hybridization. The Philadelphia chromosome was absent. Review of the literature revealed abnormalities in cases of ABL. To our knowledge, the case reported here is the first to have basophilic leukemia with monosomy 7 as the only chromosome abnormality.

• Authors: So Youn Shin, Sun Hoe Koo, Kye Cheol Kwon, Jong Woo Park, Chi Seon Ko, Deog Yeon Jo
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 172 Issue 2 Pg. 168-71 (Jan 15 2007) ISSN: 0165-4608 [Print] United States
• PMID: 17213028 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Chromosomes, Human, Pair 7 (genetics, ultrastructure)
• Diagnosis, Differential
• Humans
• Leukemia, Basophilic, Acute (drug therapy, genetics, pathology)
• Male
• Monosomy (diagnosis, genetics, pathology)