Abstract | BACKGROUND:
Cystatin C is a marker of kidney function that may also be associated with inflammation. In this study, we compared the relative strengths of association of cystatin C and estimated glomerular filtration rate (eGFR) with inflammatory biomarkers. METHODS: RESULTS:
Cystatin C concentrations had moderate correlations with CRP (r=0.15, P<0.001) and fibrinogen (r=0.26, P<0.0001); eGFR had similar correlations with CRP (r=-0.17, P=0.01) and fibrinogen (r=-0.25, P<0.001) among persons with eGFR<or=60 ml/min, but had no association with either biomarker among those with eGFR>60 ml/min (r=0.04, P=0.32; r=-0.03, P=0.38). Quartiles of cystatin C were strongly and directly associated with CRP (P=0.02) and fibrinogen (P<0.007) after multivariate adjustment. However, these associations disappeared after adjustment for creatinine clearance (P=0.26 and 0.23, respectively). CONCLUSIONS:
Cystatin C concentrations have moderate associations with CRP and fibrinogen that are not independent of creatinine clearance. Although a gold standard of kidney function is lacking, this analysis suggests that cystatin C captures an association of mildly impaired kidney function with increased inflammation.
|
Authors | David Singh, Mary A Whooley, Joachim H Ix, Sadia Ali, Michael G Shlipak |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 22
Issue 4
Pg. 1087-92
(Apr 2007)
ISSN: 0931-0509 [Print] England |
PMID | 17210589
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
- Biomarkers
- CST3 protein, human
- Cystatin C
- Cystatins
- Fibrinogen
- C-Reactive Protein
- Creatinine
|
Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(metabolism)
- C-Reactive Protein
(metabolism)
- Cohort Studies
- Coronary Artery Disease
(metabolism)
- Creatinine
(metabolism)
- Cross-Sectional Studies
- Cystatin C
- Cystatins
(blood)
- Female
- Fibrinogen
(metabolism)
- Glomerular Filtration Rate
(physiology)
- Humans
- Kidney
(physiopathology)
- Male
- Middle Aged
- Nephritis
(blood, physiopathology)
- Prospective Studies
|