Abstract | BACKGROUND AND OBJECTIVE: METHODS: Nine hundred and thirty patients who underwent bronchoscopic biopsy in Osaka City University Hospital outpatient clinic were enrolled in the study. All patients were randomly assigned to receive a 3-day course of azithromycin (500 mg/day), cefcapene pivoxil hydrochloride (300 mg/day) or no antibiotics. The primary outcome was the incidence of respiratory tract infection after bronchoscopic biopsy among the three groups. RESULTS: In the no-treatment group, nine of the 310 patients (2.9%) had respiratory tract infection after bronchoscopic biopsy. All patients with infection had abnormal bronchoscopic findings. Of the patients with respiratory tract infection, 60% were in the no-treatment group, 26.7% in the cefcapene group and 13.3% in the azithromycin group. Although not statistically significant, the incidence in the azithromycin group (0.7%) was lower than in the no-treatment group (P = 0.06). Among the patients with abnormal bronchoscopic findings, the incidence in the azithromycin group was significantly lower than that in the no-treatment group (3.0% vs. 14.8%; P = 0.02). Moreover, maximum C-reactive protein values also appeared to be lower in the azithromycin group than in the no-treatment group and the cefcapene group. CONCLUSIONS: A 3-day course of azithromycin administration is well tolerated and effective in preventing infection post bronchoscopy.
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Authors | Hiroshi Kanazawa |
Journal | Respirology (Carlton, Vic.)
(Respirology)
Vol. 12
Issue 1
Pg. 70-5
(Jan 2007)
ISSN: 1323-7799 [Print] Australia |
PMID | 17207028
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Azithromycin
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Topics |
- Adult
- Aged
- Anti-Bacterial Agents
(therapeutic use)
- Azithromycin
(therapeutic use)
- Biopsy
(adverse effects, methods)
- Bronchoscopy
(adverse effects)
- Female
- Follow-Up Studies
- Humans
- Incidence
- Male
- Middle Aged
- Respiratory Tract Infections
(epidemiology, etiology, prevention & control)
- Retrospective Studies
- Staphylococcal Infections
(epidemiology, etiology, prevention & control)
- Treatment Outcome
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