Abstract |
A 4-year-old boy with pure red cell aplasia was investigated. Immunophenotypic analysis of peripheral blood lymphocytes revealed a marked increase of CD20+ cells, which fell from 25.9% in the active stage to 9.7% in remission. The plasma contained a suppressive activity against CFU-e and BFU-e formation by the patient's bone marrow cells, which disappeared when the disease went into remission. Prednisone (2 mg/kg/day) therapy was tried for 5 weeks, but produced no improvement. Subsequently, high-dose gamma-globulin therapy induced complete remission of anemia. A lymphoblastoid B cell line obtained from the patient before therapy produced a factor that suppressed erythropoiesis but not granulopoiesis. The suppressive activity resided in the immunoglobulin fraction and was adsorbed by an anti- immunoglobulin column. These results indicate that expansion of B cells producing an immunoglobulin which suppressed erythropoiesis was involved in the pathogenesis of the disease in this patient.
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Authors | M Nagasawa, H Okawa, J Yata |
Journal | Clinical immunology and immunopathology
(Clin Immunol Immunopathol)
Vol. 61
Issue 1
Pg. 18-28
(Oct 1991)
ISSN: 0090-1229 [Print] United States |
PMID | 1720359
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunoglobulins
- gamma-Globulins
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Topics |
- B-Lymphocytes
(metabolism)
- Cell Line
- Child, Preschool
- Erythropoiesis
(immunology)
- Humans
- Immunoglobulins
(biosynthesis, immunology)
- Lymphocyte Subsets
(immunology)
- Male
- Phenotype
- Red-Cell Aplasia, Pure
(immunology, therapy)
- gamma-Globulins
(therapeutic use)
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