Abstract | BACKGROUND:
Thrombocytopenia is a common manifestation of liver cirrhosis (LC), but its underlying mechanism is not fully understood. The purpose of the present paper was to evaluate the platelet kinetics in LC patients by examining several non-invasive convenient markers. METHODS: RESULTS: There was no difference in thrombopoietin levels between LC patients and healthy controls. The RP proportion and GCI were significantly higher and the absolute RP count and glycocalicin significantly lower in LC patients than in healthy controls. These markers in ITP and LC patients were comparable, but significantly different from those in AA patients. The bone marrow megakaryocyte density in LC and ITP patients was similar, and significantly higher than in AA patients. CONCLUSIONS: Cirrhotic thrombocytopenia is a multifactorial condition involving accelerated platelet turnover and moderately impaired thrombopoiesis. Thrombopoietin deficiency is unlikely to be the primary contributor to cirrhotic thrombocytopenia.
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Authors | Mikio Kajihara, Yuka Okazaki, Shinzo Kato, Hiromasa Ishii, Yutaka Kawakami, Yasuo Ikeda, Masataka Kuwana |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 22
Issue 1
Pg. 112-8
(Jan 2007)
ISSN: 0815-9319 [Print] Australia |
PMID | 17201890
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Blood Platelets
(physiology)
- Case-Control Studies
- Chi-Square Distribution
- Female
- Humans
- Liver Cirrhosis
(blood, physiopathology)
- Male
- Middle Aged
- Platelet Count
- Purpura, Thrombocytopenic, Idiopathic
(blood, physiopathology)
- Statistics, Nonparametric
- Thrombopoietin
(blood)
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