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Diagnosis and treatment of pancreatoblastoma in China.

AbstractOBJECTIVES:
Pancreatoblastoma is an extremely rare pancreatic neoplasm. The aims of the current study were to analyze the clinical, pathological, and immunohistochemical features of pancreatoblastoma and to discuss its management.
METHODS:
The clinical data of 30 Chinese pancreatoblastoma patients (among them, 1 case was treated by authors, and the other 29 cases were reported in Chinese literature from January 1981 to December 2005) were reviewed and analyzed.
RESULTS:
Patients with pancreatoblastoma had an age range of 5 months to 42 years. There were 24 children and 6 adult cases, with a male-female ratio of 2:1 (20/10). The tumor size ranged from 2 to 20 cm in diameter. Metastases were found during the operation in 8 cases (26.7%) (among them, 66% with liver invasion and 50% with multiple metastases including spleen, kidney, and bone). Pancreatoduodenectomy was performed in 5 cases (16.7%). Nine cases (30%) received chemotherapy with vincristine, cyclophosphamide, and adriamycin. By immunohistochemistry, the tumors exhibited acinar, endocrine, and ductal differentiation. The mean time of survival was 25.5 months.
CONCLUSIONS:
These results suggest that the diagnosis of pancreatoblastoma mainly depends on the pathological findings, surgical resection is the most effective way for cure, and adjuvant chemotherapy could be a good palliative method in certain patients.
AuthorsLiping Cao, Daren Liu
JournalPancreas (Pancreas) Vol. 34 Issue 1 Pg. 92-5 (Jan 2007) ISSN: 1536-4828 [Electronic] United States
PMID17198189 (Publication Type: Case Reports, Journal Article, Review)
Topics
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
  • Child, Preschool
  • China
  • Combined Modality Therapy
  • Female
  • Humans
  • Male
  • Pancreatic Neoplasms (diagnosis, drug therapy, surgery)
  • Pancreaticoduodenectomy
  • Survival Rate
  • Treatment Outcome

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