Telithromycin inhibits the number of viable bacteria but not lymphocyte accumulation in a murine model of chronic respiratory infection.

Abstract

The 14-membered macrolides, such as clarithromycin (CAM) and erythromycin (EM), are effective against diffuse panbronchiolitis. However, there have been no studies on the effects of telithromycin (TEL) on chronic respiratory infection in vivo. In this study, we determined the effect of TEL on an experimental murine model of chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation. TEL significantly reduced the number of viable bacteria but had no effect on the proliferation of lymphocytes. In contrast, CAM decreased the number of lymphocytes but had no effect on the number of viable bacteria in the lung. These results suggest that TEL and CAM have different effects on chronic respiratory infection caused by P. aeruginosa.

• Authors: Katsunori Yanagihara, Misuzu Kuroki, Norihide Higuchi, Hideaki Ohno, Yasuhito Higashiyama, Yoshitsugu Miyazaki, Yoichi Hirakata, Hiroshi Mukae, Kazunori Tomono, Yohei Mizuta, Jun-Ichi Kadota, Kazuhiro Tsukamoto, Shigeru Kohno
• Journal: Chemotherapy (Chemotherapy) Vol. 53 Issue 1 Pg. 10-3 ( 2007) ISSN: 0009-3157 [Print] Switzerland
• PMID: 17192707 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2007 S. Karger AG, Basel.

Chemical References

• Anti-Bacterial Agents
• Ketolides
• Clarithromycin
• telithromycin

Topics

• Animals
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Biofilms (drug effects)
• Chronic Disease
• Clarithromycin (pharmacology, therapeutic use)
• Disease Models, Animal
• Ketolides (pharmacology, therapeutic use)
• Lung (immunology)
• Lymphocytes (drug effects)
• Male
• Mice
• Pseudomonas Infections (drug therapy)
• Pseudomonas aeruginosa (drug effects, isolation & purification)
• Respiratory Tract Infections (drug therapy, microbiology)