Abstract | UNLABELLED: Oropharynx is an important site of cancer in India. Global comparison indicates higher incidences in India. Radiotherapy remains an important treatment modality. Efforts to improve loco-regional treatment and prolong survival are areas of focus. Radiosensitizers in hypoxic tumors have shown promise. AIM: SETTINGS AND DESIGN: Single institutional, randomized, double-blind, placebo-controlled trial. MATERIALS AND METHODS: STATISTICAL METHODS: Non-parametric, Friedman's, Chi square, Mann-Whitney U tests. RESULTS: In the test, 15 (65%) patients had complete response, five (22%) partial/no response, two (9%) died, one (4%) lost to follow up. In the control, five (22%) patients had complete response, 16 (70%) partial/no response, one (4%) died, one (4%) lost to follow up. Short-term loco-regional response was better in the test (DF = 3, 95% Confidence Interval 0.418, 0.452, P = 0.0048). In the test group significant vomiting and one case of grade 3 neurological deficit was observed. CONCLUSION:
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Authors | S D Ullal, K K Shenoy, M R S M Pai, M N Chowta, S M N Adiga, M Dinesh, A Kamath, M S Kotian, D K Pai |
Journal | Indian journal of cancer
(Indian J Cancer)
2006 Oct-Dec
Vol. 43
Issue 4
Pg. 151-5
ISSN: 0019-509X [Print] India |
PMID | 17192685
(Publication Type: Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Radiation-Sensitizing Agents
- Triazoles
- AK 2123
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Topics |
- Adult
- Aged
- Combined Modality Therapy
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Oropharyngeal Neoplasms
(drug therapy, radiotherapy, surgery)
- Radiation-Sensitizing Agents
(therapeutic use)
- Treatment Outcome
- Triazoles
(therapeutic use)
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