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Chemotherapy of advanced dysgerminoma: trials of the Gynecologic Oncology Group.

Abstract
Between 1984 and 1989, 20 assessable patients with incompletely resected ovarian dysgerminoma were treated on two protocols of the Gynecologic Oncology Group (GOG). All patients received cisplatin, bleomycin, and either vinblastine or etoposide. More recent patients also received consolidation chemotherapy with vincristine, dactinomycin, and cyclophosphamide (VAC). Eleven patients had clinically measurable disease, and 10 responded completely. Fourteen second-look procedures were done, and all were negative. Currently, 19 of 20 patients are disease-free with median follow-up of 26 months. Cisplatin-based chemotherapy is highly effective in patients with advanced dysgerminoma.
AuthorsS D Williams, J A Blessing, K D Hatch, H D Homesley
JournalJournal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 9 Issue 11 Pg. 1950-5 (Nov 1991) ISSN: 0732-183X [Print] United States
PMID1719142 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Bleomycin
  • Dactinomycin
  • Vincristine
  • Etoposide
  • Cyclophosphamide
  • Cisplatin
Topics
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Bleomycin (administration & dosage)
  • Cisplatin (administration & dosage)
  • Combined Modality Therapy
  • Cyclophosphamide (administration & dosage)
  • Dactinomycin (administration & dosage)
  • Dysgerminoma (drug therapy, pathology, surgery)
  • Etoposide (administration & dosage)
  • Female
  • Follow-Up Studies
  • Humans
  • Ovarian Neoplasms (drug therapy, pathology, surgery)
  • Reoperation
  • Survival Analysis
  • Vincristine (administration & dosage)

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