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The role of olanzapine in the treatment of anorexia nervosa.

AbstractOBJECTIVE:
To evaluate the role of olanzapine in the treatment of anorexia nervosa.
DATA SOURCES:
Literature was obtained through searches of MEDLINE (1966-December 2006), EMBASE (1980-4th Quarter 2006), and PsycINFO (1985-December 2006) and a bibliographic review of published articles. Key terms used in the searches included anorexia nervosa, antipsychotics, eating disorders, olanzapine, and Zyprexa.
STUDY SELECTION AND DATA EXTRACTION:
All English language articles that were identified from the search were evaluated. All primary literature was included in the review.
DATA SYNTHESIS:
In several case reports and most clinical trials, patients with anorexia nervosa successfully gained weight while being treated with olanzapine. Moreover, many patients treated with olanzapine achieved a healthy body weight. Case reports and trials identified additional benefits of olanzapine, including reduction in delusional thinking; improvement in body image, sleep, depressive symptoms, adherence to treatment, and eating-disorder symptoms; and decreased agitation and premeal anxiety.
CONCLUSIONS:
Preliminary evidence supports the use of olanzapine for treatment of anorexia nervosa by demonstrating that olanzapine 2.5-15 mg daily promotes weight gain and has positive effects on associated psychological symptoms. Limitations of the reported data include small sample size, low completion rate in clinical trials, and open-label trial design. Although olanzapine appears to have a potential role in the treatment of anorexia nervosa that has been unresponsive to other therapy, randomized, placebo-controlled studies with larger sample sizes are necessary to establish its role in therapy.
AuthorsKaelen C Dunican, Dana DelDotto
JournalThe Annals of pharmacotherapy (Ann Pharmacother) Vol. 41 Issue 1 Pg. 111-5 (Jan 2007) ISSN: 1542-6270 [Electronic] United States
PMID17190846 (Publication Type: Journal Article, Review)
Chemical References
  • Benzodiazepines
  • Olanzapine
Topics
  • Anorexia Nervosa (drug therapy, epidemiology, psychology)
  • Benzodiazepines (therapeutic use)
  • Humans
  • Olanzapine
  • Treatment Outcome

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