Olanzapine-induced agranulocytosis in systemic lupus erythematosus: a case report.

Abstract

Systemic lupus erythematosus (SLE) patients may have psychiatric manifestations during the illness course. Psychotropic agents are indicated in treating these symptoms. Second-generation antipsychotics, such as risperidone, olanzapine and quetiapine, have been thought to be safer than clozapine with regard to the side effect of neutropenia or agranulocytosis. We report a case of SLE who developed agranulocytosis during the treatment with olanzapine for the SLE-related psychiatric symptoms.

• Authors: Jian-An Su, Chien-Hui Wu, Hin-Yeung Tsang
• Journal: General hospital psychiatry (Gen Hosp Psychiatry) 2007 Jan-Feb Vol. 29 Issue 1 Pg. 75-7 ISSN: 0163-8343 [Print] United States
• PMID: 17189752 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antipsychotic Agents
• Benzodiazepines
• Olanzapine

Topics

• Adult
• Agranulocytosis (chemically induced, complications)
• Antipsychotic Agents (adverse effects, therapeutic use)
• Benzodiazepines (adverse effects, therapeutic use)
• Female
• Humans
• Lupus Erythematosus, Systemic (complications, psychology)
• Olanzapine
• Psychotic Disorders (drug therapy, etiology)