Abstract | BACKGROUND: METHODS: In six obese patients (3F/3M; aged 63+/-9 yr; BMI 47.0+/-4.5 kg/m(2)) with OHS and without obstructive sleep apnoea-hypopnoea (OSAH) diurnal arterial blood gases, fasting plasma leptin concentration and CO(2) chemosensitivity were determined before and after 10.3+/-5.6 (range 6-20) months of NIMV. RESULTS: After NIMV improvements were observed in gas exchange (PaO(2) from 51.3+/-6.7 to 75.0+/-10.3 mmHg, p<0.01; PaCO(2) from 55.5+/-4.8 to 43.7+/-1.2 mmHg, p<0.01; [HCO(3)(-)] from 33.3+/-3.8 to 29.8+/-1.7 mmol/l, p<0.05) and CO(2) chemosensitivity, measured as P(0.1)/PetCO(2) slope (from 0.09+/-0.07 to 0.18+/-0.07 cmH(2)O/mmHg, p<0.05) and V(E)/PetCO(2) slope (from 0.4+/-0.3 to 0.9+/-0.5l/min/mmHg, p=0.07). Plasma leptin increased from 34.5+/-21.1 ng/ml to 50.2+/-22.9 ng/ml (p<0.01) after NIMV and changes of the P(0.1)/PetCO(2) slope correlated with percent changes of plasma leptin (r(2)=0.79, p<0.05). CONCLUSIONS: These findings suggest a possible role of leptin in the recovery of neuromuscular response to hypercapnia obtained during long-term nocturnal NIMV in OHS patients without OSAH.
|
Authors | Stefania Redolfi, Luciano Corda, Giuseppe La Piana, Sara Spandrio, Paola Prometti, Claudio Tantucci |
Journal | Respiratory medicine
(Respir Med)
Vol. 101
Issue 6
Pg. 1191-5
(Jun 2007)
ISSN: 0954-6111 [Print] England |
PMID | 17189682
(Publication Type: Journal Article)
|
Chemical References |
- Leptin
- Carbon Dioxide
- Oxygen
|
Topics |
- Aged
- Anthropometry
- Carbon Dioxide
(blood)
- Circadian Rhythm
- Fasting
(blood)
- Female
- Follow-Up Studies
- Humans
- Hypercapnia
(physiopathology)
- Leptin
(blood, physiology)
- Male
- Middle Aged
- Obesity Hypoventilation Syndrome
(blood, therapy)
- Oxygen
(blood)
- Partial Pressure
- Pilot Projects
- Pulmonary Gas Exchange
- Respiration, Artificial
(methods)
|