Abstract | PURPOSE: METHOD: As a spontaneous model of breast cancer metastasis to bone, mouse breast cancer cells, 4T1, were injected into the mammary fat pad in immunocompetent syngeneic mice. The mice were orally treated with FR202126 for 29 days. Tumor volume was measured once a week. Thirty days after the injection of the cells, the bone mineral density (BMD) of the proximal tibia was measured using peripheral quantitative computed tomography. Histomorphometric analysis of the distal femurs and the proximal tibiae was performed. To elucidate the mechanism behind the anti-osteolytic effect of FR202126, 4T1 cells were treated directly in vitro with FR202126. Cell viability was measured, and cell invasion was assessed using matrigel. RESULTS: CONCLUSION:
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Authors | Kazuaki Niikura |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 60
Issue 4
Pg. 555-62
(Sep 2007)
ISSN: 0344-5704 [Print] Germany |
PMID | 17187252
(Publication Type: Journal Article)
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Chemical References |
- 2,6-dichloro-N-(3-methyl-4-(3-methyl-2-oxo-1-imidazolidinyl)-8-quinolinyl)benzamide
- Aminoquinolines
- Benzamides
- Vacuolar Proton-Translocating ATPases
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Topics |
- Aminoquinolines
(pharmacokinetics, pharmacology)
- Animals
- Benzamides
(pharmacokinetics, pharmacology)
- Bone Neoplasms
(drug therapy, secondary)
- Cell Proliferation
(drug effects)
- Disease Models, Animal
- Female
- Mammary Neoplasms, Animal
(pathology)
- Mice
- Mice, Inbred BALB C
- Neoplasm Invasiveness
(prevention & control)
- Tumor Cells, Cultured
- Vacuolar Proton-Translocating ATPases
(antagonists & inhibitors)
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