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Comparison between the 1% and 2% ibopamine provocative test in primary open-angle glaucoma patients: sensitivity, specificity and tolerability.

AbstractPURPOSE:
To compare intraocular pressure (IOP) rise in normal individuals and primary open-angle glaucoma patients and the safety and efficacy of ibopamine eye drops in different concentrations as a provocative test for glaucoma.
METHODS:
Glaucoma patients underwent (same eye) the ibopamine provocative test with two concentrations, 1% and 2%, in a random sequence at least 3 weeks apart, but not more than 3 months. The normal individuals were randomly submitted to one of the concentrations of ibopamine (1% and 2%). The test was considered positive if there was an IOP rise greater than 3 or 4 mmHg at 30 or 45 minutes to test which subset of the test has the best sensitivity (Se)/specificity (Sp).
RESULTS:
There was no statistically significant difference in any of the IOP measurements, comparing 1% with 2% ibopamine. The IOP was significantly higher at 30 and 45 minutes with both concentrations (p < 0.001). The best sensitivity/specificity ratio was achieved with the cutoff point set as greater than 3 mmHg at 45 minutes with 2% ibopamine (area under the ROC curve: 0.864, Se: 84.6%; Sp:73.3%). All patients described a slight burning after ibopamine's instillation.
CONCLUSION:
2% ibopamine is recommended as a provocative test for glaucoma. Because both concentrations have similar ability to rise IOP, 1% ibopamine may be used to treat ocular hypotony.
AuthorsLeopoldo Magacho, Marcelus Layguel Costa, André Dessimoni, Marcos Pereira de Avila
JournalArquivos brasileiros de oftalmologia (Arq Bras Oftalmol) 2006 Sep-Oct Vol. 69 Issue 5 Pg. 695-9 ISSN: 0004-2749 [Print] Brazil
PMID17187138 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Dopamine Agonists
  • Mydriatics
  • Ophthalmic Solutions
  • ibopamine
  • Deoxyepinephrine
Topics
  • Aged
  • Deoxyepinephrine (administration & dosage, analogs & derivatives)
  • Dopamine Agonists (administration & dosage)
  • Female
  • Glaucoma, Open-Angle (diagnosis, drug therapy)
  • Humans
  • Intraocular Pressure (drug effects)
  • Male
  • Middle Aged
  • Mydriatics (administration & dosage)
  • Ophthalmic Solutions
  • Prospective Studies
  • Sensitivity and Specificity
  • Time Factors
  • Vision Tests

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