Abstract | PURPOSE: METHODS:
Glaucoma patients underwent (same eye) the ibopamine provocative test with two concentrations, 1% and 2%, in a random sequence at least 3 weeks apart, but not more than 3 months. The normal individuals were randomly submitted to one of the concentrations of ibopamine (1% and 2%). The test was considered positive if there was an IOP rise greater than 3 or 4 mmHg at 30 or 45 minutes to test which subset of the test has the best sensitivity (Se)/specificity (Sp). RESULTS: There was no statistically significant difference in any of the IOP measurements, comparing 1% with 2% ibopamine. The IOP was significantly higher at 30 and 45 minutes with both concentrations (p < 0.001). The best sensitivity/specificity ratio was achieved with the cutoff point set as greater than 3 mmHg at 45 minutes with 2% ibopamine (area under the ROC curve: 0.864, Se: 84.6%; Sp:73.3%). All patients described a slight burning after ibopamine's instillation. CONCLUSION:
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Authors | Leopoldo Magacho, Marcelus Layguel Costa, André Dessimoni, Marcos Pereira de Avila |
Journal | Arquivos brasileiros de oftalmologia
(Arq Bras Oftalmol)
2006 Sep-Oct
Vol. 69
Issue 5
Pg. 695-9
ISSN: 0004-2749 [Print] Brazil |
PMID | 17187138
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Dopamine Agonists
- Mydriatics
- Ophthalmic Solutions
- ibopamine
- Deoxyepinephrine
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Topics |
- Aged
- Deoxyepinephrine
(administration & dosage, analogs & derivatives)
- Dopamine Agonists
(administration & dosage)
- Female
- Glaucoma, Open-Angle
(diagnosis, drug therapy)
- Humans
- Intraocular Pressure
(drug effects)
- Male
- Middle Aged
- Mydriatics
(administration & dosage)
- Ophthalmic Solutions
- Prospective Studies
- Sensitivity and Specificity
- Time Factors
- Vision Tests
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