Effect of rebamipide on the colonic barrier in interleukin-10-deficient mice.
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| Abstract |
Our aim was to study the effect of a mucosal protective agent, rebamipide, on the colonic barrier and the immune response in colitis-prone interleukin-10-deficient (IL-10-/-) C57BL/6 mice infected with Helicobacter hepaticus. After sacrifice, in all mice, control, or previously infected with H. hepaticus, or previously infected and treated with rebamipide enema, a histological examination of colonic samples was performed, intestinal permeability was studied in Ussing chamber, and mesenteric lymph node proliferation and cytokine secretion were measured. Mice treated with rebamipide presented a reinforcement of the distal colonic epithelial barrier, an increase of mesenteric lymph node cells proliferation, and of IFNgamma and IL-12 secretion. These results indicate that in IL-10-/- mice with mild colitis, rectally administered rebamipide reinforces the distal colonic barrier and has a slight Th1 immuno-stimulatory effect on mesenteric lymph node cells. These properties could be helpful in the management of some inflammatory bowel diseases.
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| Authors | David Laharie, Sandrine Ménard, Corinne Asencio, Teresita Vidal-Martinez, Anne Rullier, Frank Zerbib, Céline Candalh, Francis Mégraud, Martine Heyman, Tamara Matysiak-Budnik |
| Journal | Digestive diseases and sciences (Dig Dis Sci) Vol. 52 Issue 1 Pg. 84-92 (Jan 2007) ISSN: 0163-2116 [Print] United States |
| PMID | 17186389 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't) |
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